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Catalysts | Free Full-Text | Deciphering the Role of V88L Substitution ...
v88L - Convert Link to Video - Online Video Downloader vo777 Molecular detection of the New Delhi metallo-β-lactamase clinical ... In the process of NDM evolution under an environmental pressure selection, V88L/M154L combination appears to be favorable (Bahr et al., 2017). Molecular detection of the New Delhi metallo-β-lactamase clinical ...
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The V88L substitution occurred in the β-strand and low β-sheet content in the secondary structure, as evidenced by the CD analysis data. In conclusion, the V88L substitution increases the enzyme activity and decreases the protein stability.
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PDF Deciphering the Role of V88L Substitution in NDM-24 Metallo- -Lactamase
Download scientific diagram | Proportions of various secondary structural elements in the NDM-1, NDM-5, and NDM-24 enzymes. from publication: Deciphering the Role of V88L Substitution in NDM-24...
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In this study, we evaluated the role of the V88L substitution in NDM-24 by kinetical and structural analysis. Functional results showed that V88L did not significantly increase the resistance level in the NDM-24 transformant toward penicillins, cephalosporins, meropenem, and imipenem.
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