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naRNA is a canonical neutrophil extracellular trap (NET ... - bioRxiv
naRNA as a sterile pro-inflammatory agent of early immune responses. As most pathological conditions involving NETs are sterile, our data argue that a key function of steri le NET formation is DAMP release, with naRNA-LL37 acting as a mol ecular beacon to report on PMN activation and alert tissue and other immune cells. Results
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naRNA-LL37 composite DAMPs define sterile NETs as self ... - PubMed
Our study highlights TLR-mediated RNA-LL37 sensing by PMNs as parts of a self-propagating vicious cycle that may later engulf pDC and establish chronic inflammation in psoriasis and NET-associated RNA (naRNA) as a physiologically relevant novel component.
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Transfer of NETs to naive human PMNs prompts additional NET release, promoting further inflammation. Our study thus uncovers a self-propagating vicious cycle contributing to chronic inflammation in psoriasis, and NET-associated RNA (naRNA) as a physiologically relevant NET component.